Cancer recurrence and disease-free survival are usually analysed in clinical trials, enrolling healthier and younger patients than the general cancer population, thus being unrepresentative for the real-world where comorbid elderly patients are the group with higher cancer incidence rates. As part of the effort to evaluate real-world comparative effectiveness research and cancer survival outcomes, the population-based cancer registries of Granada and Girona identified all incident cases (n=1,061) from colorectal cancer patients. Clinical information from patients diagnosed during the year 2011 and follow-up until December 31st, 2016, was collected as part of a High-Resolution European study (HIGHCARE project-Eranet TRANSCAN). Patients and tumour characteristics, type of treatment, and comorbidities were drawn from medical records.
The main objective of the proposal is to describe the pattern of comorbidities by patient, tumour and healthcare factors and to investigate the extent to which comorbidities influence time from diagnosis to cancer surgical treatment and cancer treatment.
We will describe 12 different chronic conditions based on the UK Royal College of Surgeons Charlson modified comorbidity score by patient’s, tumour and healthcare factors.
To characterize the frequency and distribution of comorbidities among colorectal patients we will use advanced visualization tools, such as interactive radar plots and heat maps.
Then, we will analyse the impact of comorbidities on cancer treatment and time-to-surgery from colorectal cancer patients, adjusted for patients’ and tumour characteristics, and type of treatment.
Finally, we will develop a web application to disseminate the results of the project and contribute promoting policy action aiming to reduce survival disparities among colorectal cancer patients affected by comorbidities.
The investigation will contribute to promote policy action aiming to reduce cancer survival disparities.
Carlos III Institute of Health, Grant/Award Number: CP17/002026
We are a team with expertise in Epidemiology, Biostatistics, Public Health, Social Sciences and Mathematics.
Senior Scientific Researcher of Epidemiology and Biostatistics
Miguel Servet I Award, Carlos III Institute of Health
Ibs.Granada, Andalusian School of Public Health.
Cuesta del Observatorio, 4, 18080
Hugo Academic Webpage
Visitor Scientist, Department of Epidemiology,
TH Chan Harvard School of Public Health, Boston, MA, U.S.A.
Assistant Professor of Epidemiology and Biostatistics (Honorary)
Department of Non-Communicable Disease Epidemiology
London School of Hygiene and Tropical Medicine, London, U.K.
LSHTM Academic Webpage
Biomedical Network Research Centers of Epidemiology and Public Health (CIBERESP), ISCIII, Madrid, Spain.
Research Assistant of Environmental Epidemiology. PhD student.
Biomedical Research Institute of Granada, ibs Granada. University of Granada. Andalusian School of Public Health. Cuesta del Observatorio, 4, 18080 Granada, Spain
Biomedical Network Research Centers of Epidemiology and Public Health (CIBERESP), ISCIII, Madrid, Spain
Research Support Unit. San Cecilio Clinical Hospital, Granada.
Pollution Surveillance and Control Laboratory. Environment and Water Agency, Ministry of Environment, Junta de Andalucía.